NC State Wolfpack vs Pittsburgh Panthers Prediction, Odds and Picks for Today, 10/25/25

The Pittsburgh Panthers have been rolling ever since making a switch at QB. Following back-to-back losses, Mason Heintschel took over for Eli Holstein and led the Panthers to 3 straight wins with an average win-margin of 20.3 PPG — a stretch that included an upset win on the road at Florida State. The real star of the show for Pitt, however, has been the defense. Pittsburgh ranks 4th in FBS in rushing defense, allowing only 82.4 yards per game on the ground, and 12th in EPA/rush allowed.

The Wolfpack likes to run the ball, though they rank 82nd in rushing success rate and will likely have to rely on QB CJ Bailey. The sophomore QB is solid, but he’s somewhat turnover prone and matches up against a Panthers defense that ranks 28th in turnovers gained. Pittsburgh has some mojo rolling right now, and I’m riding the wave and backing the Panthers to cover at home in this spot.

NC State vs Pittsburgh prediction: Pittsburgh Panthers -6.5 (-110) available at time of publishing. Playable at that number or better.

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