Nebraska Cornhuskers vs Penn State Nittany Lions Prediction, Odds and Picks for Saturday, 11/22/25

We head to the B1G on Saturday night for what was no doubt designed to be a late-season blockbuster game between the Nebraska Cornhuskers and Penn State Nittany Lions. It turns out, the Lord had other plans, as they like to say, and both teams have lost their star QBs for the season. Now, what was once intended to be a battle for a potential playoff spot has turned into a ho-hum Saturday night. Still, there is opportunity to make money here, and I think the way we do that is to back Penn State to cover -8.

My expectation is that the public will be down on Penn State after they fell on hard times, forgetting just how much elite talent is scattered all over this roster. Indiana almost found out the hard way, and this team is far from a dumpster fire. Savvy bettors should notice that Penn State has started to figure things out again, and they have an elite defense with a capable-enough offense. They can run the ball dominantly, and Nebraska ranks 91^st in rushing yards allowed. It will be cold in State Park for a 7:00 pm kickoff, perfect conditions for defense and running the ball. The argument against this spread is that we would want it under 7 points, but I struggle to see how Nebraska will move the ball much at all in this game. I think this one could spiral out of control for Matt Rhule’s bunch in a hostile, inhospitable road environment against a team still hungry to prove something (and that can still get bowl eligible after all they’ve been through), and if Nebraska is forced to put too much on the shoulders of a new QB in only his second start, that could spell disaster. Give me the Nittany Lions here.

Nebraska vs Penn State Prediction: Penn State -8 (-110) available at the time of publishing. Playable to -9.5.