Northwestern Wildcats vs Nebraska Cornhuskers Prediction, Odds and Picks for Today, 10/25/25

The Nebraska Cornhuskers are coming off a poorly-played defeat against Minnesota last weekend. Nebraska lost 24-6 on the road, and the Cornhuskers allowed their starting quarterback Dylan Raiola to be sacked 9 times. Nebraska has the top-rated defense in the FBS against the pass, and it held up in this game. However, Nebraska could not stop Minnesota’s rushing attack, allowing 186 yards on the ground. Nebraska will try to bounce back this weekend when it faces-off against the Northwestern Wildcats. Northwestern is off to a surprising 5-2 start this season, winners of 4 straight — including wins against UCLA, Penn State, and Purdue. The Wildcats played Purdue last weekend, and they shutout the Boilermakers 19-0. Northwestern’s defense currently ranks 22nd in the FBS in total defense. The Wildcats allow on average 305 yards per game this season.

An early telltale sign of determined success for Nebraska is if it can keep their quarterback upright. In Nebraska’s losses this season, the Huskers allowed 7 sacks against Michigan, and 9 sacks against Minnesota. Head coach Matt Rhule addressed the protection issue after the loss against Minnesota. He inferred that the problem is not only on the offensive linemen, but their running backs are also not picking up opposing blitzes well enough. He finished by stating “We have all the tools to handle that and we just didn’t do it.” Saturday’s game against Northwestern should be a good bounce-back spot for Nebraska’s protection unit. Although Northwestern has excelled on defense this season, it has not frequently gotten to opposing quarterbacks.  In 7 games this season, Northwestern has only sacked their opponents 11 times. Their current sack leader is defensive lineman Anto Saka with 3 sacks. With a week to prepare and focus on the problem, I believe coach Rhule will bring a solid gameplan to keep Raiola upright, allowing Nebraska’s talent to guide them to victory on their home field.

Northwestern vs Nebraska prediction: Nebraska Cornhuskers -7 is available at the time of publishing. Playable at that number.

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