Notre Dame Fighting Irish vs Pittsburgh Panthers Prediction, Odds and Picks for Today, 11/15/25

Everyone knows both teams can move the football, but the Irish defense has quietly become one of the most consistent units in the country. In 5 of its last 6 wins, Notre Dame has held opponents to 13 points or fewer. That includes capable offenses like Arkansas, Boise State, NC State, and Navy — all teams that can score. Meanwhile, Pitt’s offense has looked sharp against lesser defenses, but this is a completely different animal. This looks more like a prototypical Marcus Freeman defense the more the weeks go by.

If the Irish offense produces in the mid-30s, as they’re fully capable of doing, and the defense holds Pittsburgh under two touchdowns, that lands this game squarely below the total. Let’s also forget that the Irish lead with the run on the shoulders of Jeremiyah Love — that also translates to longer drives, fewer possessions and fewer opportunities for the Panthers in particular.

Notre Dame vs Pitt prediction: Under 55.5 (-115) available at time of publishing. Playable to 55.

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