Oklahoma Sooners vs South Carolina Gamecocks Prediction, Odds and Picks for Today, 10/18/25

This is a great spot to fade the Sooners, who looked lost last week against the unranked Longhorns of Texas in Red River. Yes, OU kept its ranking, but there are so many questions that linger as to what iteration of Boomer Sooner shows up in Columbia. The Gamecocks, meanwhile, come in off the radar and forgotten — a perfect spot to step in.

Remember, the Gamecocks were ranked once upon a time this season until losses to Vanderbilt, at LSU, and at Mizzou derailed them. We must also point out that all 3 of these teams are ranked, so this isn’t Carolina’s first rodeo in a matchup of this caliber. Losing to Texas is a tough pill to swallow for OU, but the Sooners did so turning the ball over 4 times and giving up points on special teams. In this game, they will face a quarterback that, pound-for-pound, could be better than Arch Manning in one Lanorris Sellers. Sellers is more dynamic, and he can exploit the Oklahoma defense — which at times looked porous against the run. Add in the fact that the Sooners will step into a notoriously unfriendly setting, and this is a spot tailor-made for the Gamecocks to exploit. The fact that Oklahoma is spotting less than a converted touchdown to a .500 football team says it all. South Carolina outright.

Oklahoma vs. South Carolina prediction: South Carolina ML (+175) available at time of publishing. Playable at number posted.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Oklahoma vs South Carolina predictions.