Oklahoma State Cowboys vs Texas Tech Red Raiders Prediction, Odds and Picks for Saturday, 10/25/25

Do we really have a nearly 40-point spread in a major conference game? That crazy line is what we are looking at when the Oklahoma State Cowboys take on the Texas Tech Red Raiders in Lubbock on Saturday afternoon. That is what happens when the Cowboys fire their coach midseason and watch the program implode from there. They have been clobbered in all 4 conference games, losing by at least 3 possessions in each. Now, they draw the Red Raiders, who are almost certain the best team in the league but are looking to get right after a loss at Arizona State last week. There is little doubt that the Red Raiders will smash the Cowboys, but it is awfully difficult to bet on a 38-pt spread. Instead, I think the better play is on the over, especially when Texas Tech can cover all or most of this number by themselves. I’ll take the game total over 56.5.

Texas Tech might still be playing without their starting QB, who missed the ASU game and who will likely be listed as questionable right up until kickoff this week. Not to worry, as backup QB Will Hammond is perfectly capable of running this offense, and they don’t really dial things back with him under center. This is a Red Raider team that is stacked in the trenches on both sides of the ball, and they should overpower the Cowboys. The question is just how badly they will beat the Cowboys, and whether the Cowboys can chip in at least a little bit toward this total. I think that is probably the best play though, and I expect this game will end up around the 48-10 range.

Oklahoma State vs Texas Tech Prediction: Over 56.5 (-110) available at the time of publishing. Playable at that number.