Old Dominion Monarchs vs James Madison Dukes Prediction, Odds and Picks for Saturday, 10/18/25

Let’s break it down. The Monarchs quietly were a bit of a commodity leading into last week’s match-up with Marshall. The market catching ODU early was cashing tickets week in and week out, and they continued to press and hammer the Freight Line last week when they were spotting over two converted touchdowns on the road at the Thundering Herd.

However, Marshall would not only cover but light up Old Dominion while they were at. Forget the points, Marshall would win outright by 14 as the hosts and with that ODU’s stock went into the gutter. Now, stepping in here, we get Old Dominion at a better price than we would have if they had done what they were supposed to do last week in Huntington.

James Madison quietly has ascended to 5-1, their only loss a tooth-and-nail defeat at Louisville that was a lot scorer than the scoreboard let on. But let us remind you who ODU has taken down already this season: Virginia Tech in Blacksburg and they gave #3 Indiana a game in Hoosierville. This is a dangerous football team and one bad week of football doesn’t erase that. ODU responds big here.

Old Dominion vs. James Madison prediction: Old Dominion +100 (Money Line) available at time of publishing. Playable to number posted.