Ole Miss Rebels vs Mississippi State Bulldogs Prediction, Odds and Picks for Friday, 11/28/25

The annual Egg Bowl is one of the best rivalries in college football and Saturday’s installment has the potential to be one of the more consequential games in this rivalry on Friday, as Ole Miss needs a win to secure a spot in the College Football Playoff, while the Bulldogs are looking to pick up a victory to make a bowl game after starting the season with little to no expectations. This is also a game where there are a ton of off-field distractions at hand, as the Rebels are expected to lose head coach Lane Kiffin at the end of the regular season based on recent reporting. Given the fact that this could be Kiffin’s last game as the head coach in Oxford and he’s likely headed to another team within the SEC, it would be fair to question if both he and his team are in the right frame of mind to hit the road and play in an extremely important game to clinch a College Football Playoff berth against an opponent that is better than their record.

I successfully backed Mississippi State against multiple SEC foes this season, and I’m going back to the well with the Bulldogs at home against an Ole Miss team that has to be in a strange spot mentally at the moment. Ole Miss just struggled to put away Florida at home in its last contest and Mississippi State is certainly a better team than the reeling Gators. Furthermore, the Bulldogs will be at home, where they’ve excelled at this season, already beating Arizona State as an underdog of a touchdown and nearly upsetting both Texas and Tennessee as a home ‘dog of around a touchdown. Ole Miss quarterback Trinidad Chambliss has undoubtedly been a pleasant surprise this season, but playing on the road in this type of rivalry game will still be a new experience for a player in Chambliss that is due for some turnover regression sooner rather than later. 

As for the other side of the ball, the Mississippi State offense should be able to keep the Bulldogs in this game, especially against an Ole Miss defense that has struggled in a number of conference games this season. The Mississippi State offense is a veteran group that sits in the top 20 nationally in rushing success rate and points per quality drive. We can expect Jeff Lebby’s group to be the one to bring the energy and punch Ole Miss in the mouth early on, which should lead to a fun back-and-forth game. We just saw Ole Miss lose a similar “win and in” type of game a season ago at Florida as a significant favorite, and it wouldn’t surprise me if history repeated itself on Friday.

Ole Miss vs Mississippi State prediction: Mississippi State +7.5 available at time of publishing. Playable to +7

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