Penn State Nittany Lions vs Clemson Tigers Prediction, Odds and Picks for Saturday, 12/27/25

The Penn State Nittany Lions; The Clemson Tigers; at Yankee Stadium? Seems like something out of a movie. No, it’s just the Pinstripe Bowl. In the beginning of the regular season, if you told us these two would be squaring off, we would have thought it would have been the College Football Playoff. Instead, two of the most storied programs in college football meet in the Bronx before New Year’s Day. The question going in is which team can handle that better. The signs point to the Tigers.

We can point out the number that this opened at with Clemson spotting a field goal plus the hook to PSU. That type of price typically lends to a favorite number because it makes the field goal plus the half point attractive to take with the underdog. So far the market has bitten down and the line has moved to a field goal accordingly. But that’s not the only reason why we like the Tigers here. Let’s talk about coaching. Terry Smith or Dabo Swinney. Who are you taking? Dabo, of course. Swinney will find a way to craft a narrative to get his team fired up for this opportunity even if their season went off the rails. Penn State may have a lot more local support in New York but none of that actually matters against a team like Clemson who is built for stages even like this one. Tigers roll.

Penn State Nittany Lions vs Clemson Tigers prediction: Clemson -3 (-110) available at time of publishing. Playable at the number.