Pittsburgh Panthers vs Stanford Cardinal Prediction, Odds and Picks for Saturday, 11/01/25

The Pittsburgh Panthers currently sit near the top of the ACC standings with a record of 6-2 and a conference record of 4-1. They will try to continue their four-game winning streak with a road victory against the Stanford Cardinal. Pittsburgh is coming off an offensive explosion in a game they defeated North Carolina State 53-34. Freshman quarterback Mason Heintschel threw for an impressive 423 yards and 3 touchdowns in the win. Heintschel replaced Eli Holstein earlier in the season, and the freshman has filled in well, accumulating over 1200 yards passing in four starts. Stanford has a losing record, but they are currently 2-3 in conference. They lost their last game 42-7 against Miami, but prior to that they beat Florida State 20-13 at Stanford Stadium. The Cardinal are currently 3-0 on their home field. Quarterback Ben Gulbranson is the Cardinal quarterback. He has thrown for 1585 yards, 8 touchdowns, and 7 interceptions this season.

The Panthers have a gauntlet of ACC games in front of them after their game against Stanford. On the schedule following this game is Notre Dame, Georgia Tech, and Miami. On paper this is a dangerous look ahead spot for Pittsburgh against a Stanford team that already beat Florida State, but I think Pittsburgh will be ready for the challenge and well-prepared. The offense for Pittsburgh has been on fire in the past four weeks. They have scored 165 points during the winning streak, and Heintschel is coming off being named ACC Rookie of the Week after becoming the first freshman in any Power Four school to throw for 400 yards and three touchdowns in a single game this season. Heintschel should be able to continue his run against a Stanford team that ranks 132nd in the FBS against the pass by allowing on average 292 yards passing per game. I don’t see the Stanford defense being the unit to slow down Pittsburgh’s offense.

Pittsburgh -14.5 is available at the time of publishing. Playable at that number.