Pittsburgh Panthers vs West Virginia Mountaineers Prediction, Odds and Picks for Tomorrow, 09/13/25

The Pittsburgh Panthers head to a dangerous Morgantown atmosphere to take on the West Virginia Mountaineers in the rivalry dubbed ‘The Backyard Brawl.’ Now, both squads are coming off polar opposite results in Week 2 with the Panthers smashing Central Michigan and the Mountaineers dropping one at home against Ohio. Despite the difference in recent success, this matchup has been decided within one touchdown in 6 of the last 8 meetings and I expect it to be close once again. This is a get-right game for West Virginia in what is likely the most important home game on the schedule in 2025, I expect the Mountaineers to be up for this one.

The offense is coming off a shaky performance, but the Ohio defense is incredibly underrated and the Bobcats have a front seven that could compete in a power 5 conference. The bright spot for the Mountaineers has been the defense; West Virginia forced 3 turnovers in the pass game and held the Bobcats to under 4.0 yards per carry. The WVU defense is a big step up compared to Pittsburgh’s early-season competition and I expect the unit to give the offense plenty of opportunities to keep this within reach. After falling in a 4-point loss in last season’s meeting, I’ll take West Virginia to keep things close once again.

Pittsburgh vs West Virginia prediction: West Virginia +7.5 (-110) available at time of publishing. Playable down to +6.5 (-110).