Purdue Boilermakers vs Michigan Wolverines Prediction, Odds and Picks for Today, 11/01/25

This one is about finding value where the market isn’t looking. Purdue has no public appeal — a 2–6 team that finished dead last in the Big Ten a season ago — so the betting market naturally pushes against it. Michigan, on the other hand, is still very much alive in the playoff hunt if it can win out and take down Ohio State. That’s the storyline everyone knows, and it’s baked heavily into this number.

The Wolverines are college football royalty, and with that brand name comes a premium. You’re paying for the helmet decal, not the matchup. Purdue doesn’t need to be special here; they just need to be competent. Michigan likely wins comfortably, but covering 3 full touchdowns requires 4 solid quarters of focus — and that’s a tall ask against a scrappy opponent looking to play spoiler with nowhere to go but upwards.

There is no need to overanalyze stats or personnel in this one. The value sits quietly under the rug with the Boilermakers. Take the points, close your eyes, and don’t ask questions.

Purdue vs. Michigan prediction: Purdue Boilermakers +21 (-110) available at time of publishing. Playable at number posted.

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