Purdue Boilermakers vs Notre Dame Fighting Irish Prediction, Odds and Picks for Saturday, 09/20/25

We’re still going to continue our attack on Notre Dame as all the pieces of the puzzle warrant such a move. Notre Dame has lost two back-to-back bitter defeats but Saturday’s last-minute loss to the Aggies was far more egregious than their opening week stumble at Miami. A missed extra point by way of a botched snap ultimately did the Irish in, that’s what you will hear. But what about the fact that Notre Dame’s defense gave up 40 points in South Bend? One can blame a loss on a moment, but the entire body of week throughout that contest illuminates why A&M went into Notre Dame Stadium and stole a win.

Nevertheless, the Irish are still ranked and still carrying that betting momentum from last season where they ran off 11 straight wins straight up and against the spread. They are still overvalued even if their last two showings were gut-wrenching to backers and Irish fans alike. Notre Dame has to get over last week’s debacle, Purdue meanwhile will be coming in with nothing to lose and everything to gain against a defense that is uncertain. No reason to be laying this kind of price with the Irish here, at all. Boiler up.

Purdue vs. Notre Dame prediction:  Purdue +24.5 (-110) available at time of publishing. Playable to +24.