Rutgers Scarlet Knights vs Purdue Boilermakers Prediction, Odds and Picks for Saturday, 10/25/25

The Boilermakers aren’t a team that exactly have raised eyebrows in recent memory. Last year, Purdue was the proverbial hackey sack that got kicked around the Big Ten and the favorite chew toy of many. On cue, the Boilers have picked up where they have left off, dropping their last five overall, getting whacked in every one of these contests. Rutgers meanwhile comes in on a four-game skid of their own but they have more wins on the year, sitting at 3-4 compared to Purdue’s 2-5. However, are the Scarlet Knights a team that should be spotting points on the road in this situation? Probably not. The Knights barely got by Ohio in their season opener as a 15.5-point favorite. Yes, they did what they had to do against Miami Ohio and Norfolk State but that was in Piscataway. It’s a different task to win in West Lafayette and be expected to do so.

The line also speaks to us. The Boilers are not even being given a field goal and this is a team that has lost every game this year by a touchdown or more. If Rutgers were worthy of a road favorite designation, they’d be laying more here but they are not. Purdue gets off the snide. Boilers outright.

Rutgers vs. Purdue prediction: Purdue ML (+115) available at the time of publishing. Playable at that number or better.