Samford Bulldogs vs Texas A&M Aggies Prediction, Odds and Picks for Saturday, 11/22/25

Anytime a team is laying north of 50 points in mid-November, bettors should immediately ask a simple question: What is the motivation for the favorite to run up the score? In this case, Texas A&M has every reason not to. The Aggies are days away from the biggest game of their season — a Thanksgiving weekend showdown in Austin against Texas. That matchup is not just about rivalry pride; it’s effectively A&M’s ticket to Atlanta. If the Aggies go into Austin and beat the Longhorns, they’ll position themselves to play for the SEC Championship and perhaps even grab a seat inside the top four of the College Football Playoff. Everything they’ve worked for funnels directly into next weekend.

Which leads us to this: What benefit is there for A&M to empty the tank against Samford? The honest answer is none. The Bulldogs are essentially a live-action scrimmage for the Aggies — a tune-up at best. There is no incentive to put anything meaningful on tape, risk injuries to starters, or burn high-value plays that Texas could scout. This is a pure manage-and-move-on spot for the home side. And that opens multiple pathways for Samford to cover. First, A&M has to actually score 56 just to push this number to the threshold. That’s no small ask, even against an FCS opponent, especially when the second team — and likely the third team — will play the majority of the second half. A&M may get into the 40’s, maybe the low 50’s at most, but surpassing 55.5 requires both aggression and intention, neither of which align with where the Aggies are mentally right now. Second, if Samford even scratches the scoreboard — a field goal, a broken play, a late touchdown against A&M’s deep reserves — the Aggies would need close to 60 to beat this number. That’s probably not going to happen here. There is no reason for the Aggies to get cute.

Samford vs. Texas A&M prediction: Samford +55.5 (-110) available at time of publishing. Playable at the number.