SMU Mustangs vs Clemson Tigers Prediction, Odds and Picks for Today, 10/18/25

The Clemson Tigers have looked like a new team after a bye week hit at the right time following a rough loss at home against unranked Syracuse. After back-to-back dominant road wins, the Tigers return to Death Valley to take on a quality SMU side in a matchup that has seen absurd line movement. Less than a week ago, Clemson was -11, and it has moved all the way down to -5.5 in some spots due to QB Cade Klubnik being questionable. Similarly, the over/under has dropped from 55.0 to 51.5 since October 12.

With a stout defense and offense that prefers slow, methodical drives, I expect Clemson to control the tempo of this game. The Tigers offense though has been a bit of a disappointment with a preseason Heisman hopeful at quarterback, ranking 86th in offensive success rate. On the contrary, the defense has been solid at stalling drives, ranking 21st in points per quality drive and top-40 in red zone defense. I’ll follow the line movement in this spot and take the under.

SMU vs Clemson prediction: Under 51.5 (-110) available at time of publishing. Playable at that number or better.

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