South Carolina Gamecocks vs Missouri Tigers Prediction, Odds and Picks for Saturday, 09/20/25

The Missouri Tigers will open SEC play with a home game against the South Carolina Gamecocks. Missouri is 3-0 to start the season, with wins against Central Arkansas, Kansas, and Louisiana. Each win was by double digits. Quarterback Brady Cook’s time came to an end at Missouri and the Tigers’ have moved to senior Beau Pribula. Pribula has been excellent to start his 2025 season, throwing for 791 yards and 7 touchdowns. South Carolina is coming off a difficult to swallow loss last week. They lost on their home field 31-7 to Vanderbilt. Quarterback standout LaNorris Sellers went down early with a head injury in this game. His status remains in question heading into this weekend.

The biggest storyline heading into this game is the status of Sellers, and if he will be ready to go by Saturday. Last year’s freshman of the year is a key part to this team’s success and they will need him healthy, especially as South Carolina enters a stretch in their schedule where they play a ranked opponent in six of their next seven contests. I think this line has already adjusted for Sellers potentially sitting out. Even if the sophomore doesn’t suit up, I still think South Carolina can cover this total. Missouri’s offense has performed well above offseason predictions. Through three games, this group has shown potential to be one of head coach Eliah Drinkwitz best units yet. But I don’t expect things to go as smoothly this week as this will be this unit’s first test against an SEC defense. It’s true that nothing went right last week for the Gamecocks against Vanderbilt, a team that is better than they are giving credit for. But I think they can get back on track this week with the run against a shaky Missouri rushing defense. I’ll take this early thinking Sellers won’t play, and if he can give it a go in what feels like a must win game for South Carolina, I’ll consider it a plus.

South Carolina +10.5 is available at the time of publishing. Playable at that number.