South Carolina Gamecocks vs Missouri Tigers Prediction, Odds and Picks for Today, 09/20/25

The Missouri Tigers will open SEC play with a home game against the South Carolina Gamecocks. Missouri is 3-0 to start the season with wins against Central Arkansas, Kansas, and Louisiana. Each win was by double digits. Quarterback Brady Cook’s time came to an end at Missouri and the Tigers’ have since moved to senior Beau Pribula. Pribula has been excellent, throwing for 791 yards and 7 touchdowns. South Carolina comes into this contest off a difficult-to-swallow defeat last week. They lost on their home field 31-7 to Vanderbilt. Quarterback standout LaNorris Sellers went down early with a head injury in this game. His status remains in question heading into this weekend.

The biggest storyline heading into this game is the status of Sellers, and if he will be ready to go by Saturday. Last year’s freshman of the year is a key part to this team’s success and they will need him healthy, especially as South Carolina enters a stretch in their schedule where they play a ranked opponent in six of their next seven contests. I think this line has already adjusted for Sellers potentially sitting out. Even if the sophomore doesn’t suit up, I still think South Carolina can cover this number.

Missouri’s offense has performed well above offseason predictions. Through three games, this group has shown potential to be one of head coach Eliah Drinkwitz’s best units yet, but I don’t expect things to go as smoothly this week — as this will be this unit’s first test against an SEC defense. It’s true that nothing went right last week for the Gamecocks against Vanderbilt, a team that is better than they are given credit for, but I think they can get back on track this week via the run game against a shaky Missouri rushing defense. I’ll take this early thinking Sellers won’t play, and if he can give it a go in what feels like a must win game for South Carolina, I’ll consider it a plus.

South Carolina vs Missouri prediction: South Carolina Gamecocks +10.5 is available at the time of publishing. Playable at that number.

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