South Carolina Gamecocks vs Ole Miss Rebels Prediction, Odds and Picks for Saturday, 11/01/25

We can correlate the Gamecocks with our first take on this matchup. If we’re expecting a high-scoring game, the academic move is to take the points — and that’s exactly what we’re doing here. In a contest where both teams are capable of trading scores, that +12.5 cushion suddenly looks very attractive.

Ole Miss can put up points, no question about it. But as we mentioned in the Over analysis, their defense hasn’t exactly been airtight. The Rebels have feasted on inconsistent or one-dimensional offenses — Oklahoma, Kentucky, LSU, Washington State, Tulane — but against teams with legitimate firepower like Georgia or Arkansas, they’ve surrendered 35 or more points and split those results. That’s not a formula for comfortably covering double digits.

South Carolina fits the mold of the kind of team that can stress this defense. When LaNorris Sellers gets going, the Gamecocks can generate chunk plays and sustain drives. Combine that with an Ole Miss defense that struggles to get off the field, and you have a recipe for a back-and-forth affair where every possession matters.

If this turns into the shootout we expect, the amount of points here is simply too generous. The Gamecocks stay within striking distance — and could make things very interesting late. They may even pull the upset. Take the points.

South Carolina vs. Ole Miss prediction: South Carolina +12.5 (-110) available at  time of publishing. Playable to +12.

We’re leading this one with the total, because that’s where the value lies. Everyone knows what Ole Miss can do offensively — they move fast, score in bunches, and can light up a scoreboard in a hurry. The real question is whether their defense can stop anyone. Before you answer “yes,” take a look at who they’ve actually contained.

Oklahoma? A team plagued by inconsistency. Kentucky? Not exactly an offensive juggernaut. LSU? Struggling to find rhythm all season and now without its head coach. Washington State and Tulane? Solid mid-tier offenses, but not the kind a ranked Rebels team should be sweating.

When Ole Miss has faced legitimate offensive threats — teams like Georgia or even Arkansas — the results tell the story. They’ve allowed 35 or more points in both, splitting those games 1–1. South Carolina fits that same mold when LaNorris Sellers gets rolling. The Gamecocks can move the ball, stretch the field, and they’ll find cracks in this Ole Miss defense just as others have.

With both offenses capable and neither defense built to dominate, this has all the makings of a track meet. Expect plenty of fireworks and little resistance. The over 54.5 looks very live — and 60 points looks elementary in this contest.

South Carolina vs. Ole Miss prediction: Over 54.5 (-110) available at time of publishing. Playable to Over 55.