South Carolina Gamecocks vs Ole Miss Rebels Prediction, Odds and Picks for Today, 11/01/25

We can correlate the Gamecocks with our take on the total in this matchup. If we’re expecting a high-scoring game, the academic move is to take the points — and that’s exactly what we’re doing here. In a contest where both teams are capable of trading scores, that +12.5 cushion suddenly looks very attractive.

Ole Miss can put up points, no question about it. But as we mentioned in the total analysis, the Rebels defense hasn’t exactly been airtight. They have feasted on inconsistent or one-dimensional offenses — Oklahoma, Kentucky, LSU, Washington State, Tulane — but against teams with legitimate firepower like Georgia or Arkansas, they’ve surrendered 35 or more points and split those results. That’s not a formula for comfortably covering double digits.

South Carolina fits the mold of the kind of team that can stress this defense. When LaNorris Sellers gets going, the Gamecocks can generate chunk plays and sustain drives. Combine that with an Ole Miss defense that struggles to get off the field, and you have a recipe for a back-and-forth affair where every possession matters.

If this turns into the shootout we expect, the amount of points here is simply too generous. The Gamecocks stay within striking distance, and could make things very interesting late. They may even pull the upset. Take the points.

South Carolina vs. Ole Miss prediction: South Carolina Gamecocks +12.5 (-110) available at  time of publishing. Playable to +12.

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