South Dakota Coyotes vs Iowa State Cyclones Prediction, Odds and Picks for Saturday, 08/30/25

Last week, we faded the Cyclones when they were in Dublin, squaring off for Farmageddon against hated rival Kansas State. In the college football season kickoff of two ranked sides, ISU delivered the goods in what was a thrilling 24-21 win. Some takeaways to consider, K-State if one watched the game, actually controlled most of the game flow until things opened up late in the second-half, but even then the Wildcats matched them in stride. It was a sloppy affair with a lot of variance involved, the Cyclones were the benefactors of that and emerged with the W. Add in the emotional nature of the win and the fact that Cy-Hawk is up next, this has a sandwich game feel to it which makes the Coyotes dangerous.

A little bit about South Dakota, they are #5 in the Coaches Polls for FCS teams in the pre-season and are not a team to come in flat against or look past, ISU, included. The spot screams trap and with all the mayhem that ensures in Week One, there is at least one FCS-FBS upset, generally speaking. If we were to scan the list for potential candidates, this would have to be near the top, if the not at the top. Make no mistake, South Dakota will see this as an opportunity and if the Coyotes show up while the Clones are flat-footed, not only do we cover here, but an upset is very much possible.

South Dakota vs. Iowa State prediction: South Dakota (+15.5) available at time of publishing. Playable to +15.