Southeastern Louisiana Lions

Southeastern Louisiana Lions vs LSU Tigers Prediction, Odds and Picks for Tomorrow, 09/20/25

Tiger StadiumESPN
Southeastern Louisiana
2-1
Southeastern Louisiana
Tomorrow
LSU
3-0
LSU
LSU Tigers
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Southeastern Louisiana vs LSU Pickswise Expert Predictions

Southeastern Louisiana Lions
Point Spread Pick
LSU -39.5(-110)

LSU is set to pay $750,000 to SE Louisiana for the Lions to visit Tiger Stadium this weekend, and things could get ugly fast. SE Louisiana has faced one FBS opponent this season, being shut out 24-0 against Louisiana Tech. The LSU offense has had its struggles, ranking 91st in offensive success rate, but the talent gap is too large to ignore. LSU’s playmakers should shine in this one against a far inferior opponent, and I expect the Tigers to use this week as a tune-up game to correct any issues that could be persisting within the offense prior to SEC play.

LSU has one of the most talented defensive units in the country, let alone the SEC. Considering the Lions failed to put up a single point against Louisiana Tech, this could very well end up being a complete shutout for the LSU defense. I’m not overthinking this one and will be going with LSU to win big and cover at home.

SE Louisiana vs LSU prediction: LSU -39.5 (-110) available at time of publishing. Playable at that number or better.

LSU Tigers
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Ryan Bunnell

Ryan is a die-hard sports fan with a passion for crunching numbers and finding winning picks. He works on the Pickswise social media team and recently began handicapping MLB games. He has years of experience delivering winning picks in both college football and the UFC and is looking to expand his areas of expertise. For Ryan Bunnell media enquiries, please email contact@pickswise.com.
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