Southern Mississippi Golden Eagles vs Arkansas State Red Wolves Prediction, Odds and Picks for Today, 11/08/25

The Southern Miss Golden Eagles are atop the Sun Belt West standings heading into a tough road matchup against an Arkansas State Red Wolves squad that has really turned things around on a 4-0 stretch. Despite the recent success, the defense continues to be a major concern for the Red Wolves. Arkansas State surrenders over 405 yards per game, ranking 127th in defense success rate and 125th in points per quality drive. On the contrary, the Southern Miss offense has been quite consistent in 2025.

The Golden Eagles have a top-40 scoring offense averaging 33 points per game, and have done an excellent job of taking care of the ball with the best turnover margin in the country (+12). Arkansas State, on the other hand, has a -2 turnover margin and has struggled with finishing drives this season – ranking 115th in points per quality drive. The Golden Eagles are strong in several areas that the Red Wolves struggle with; I’ll take the favorites to cover on the road.

Southern Miss vs Arkansas State prediction: Southern Miss Golden Eagles -4.5 (-110) available at time of publishing. Playable up to -5.5 (-110).

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