Stanford Cardinal vs Virginia Cavaliers Prediction, Odds and Picks for Today, 09/20/25

The Stanford Cardinal makes one of their dreaded cross-country ACC trips, this time to face the Virginia Cavaliers. Neither team is very good, but there is a lot of hope in Charlottsville these days. The Cavaliers opened the season 2-1 with resounding wins over weaker opponents William & Mary and Coastal Carolina. They lost at NC State in a game in which they posted over 500 yards of offense, but somehow couldn’t score in the fourth quarter when it mattered most. Stanford, on the other hand, opened with a heartbreaking loss at Hawaii, followed by a beating at BYU, but then got its first conference win against Boston College a week ago. This spread is up to a dicey -15.5, which is too risky for me in a game between a couple of not-so-good teams. Instead, I will back the offenses on Saturday night and take the game total over 49.

Virginia has some exciting things going on the offensive side of the ball. North Texas transfer QB Chandler Morris comes in after one of the more prolific passing seasons in history. He was certainly a product of the North Texas system, but UVA is trying to run some similar pass-first principles and wants to score lots of points. The Cavaliers defense will be a work in progress all season though, which also has me on the over. It is hard to know what we will get from Stanford, but this is not a matchup with an elite defense by any means. The Cardinal will have to push the offense to try to keep up with Virginia, so I am betting on them being able to keep pace a little bit. I’ll take the over.

Stanford vs Virginia Prediction: Over 49 (-110) available at the time of publishing. Playable at that number.

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