TCU Horned Frogs vs Houston Cougars Prediction, Odds and Picks for Saturday, 11/22/25

The Houston Cougars host the TCU Horned Frogs on Saturday afternoon in a Big 12 battle. Houston is still at least theoretically alive for the Big 12 championship game at 5-2 in the conference, and they have had a fantastic season that has exceeded all expectations. In all honestly, this is a really good team that isn’t flashy, but they just keep doing the little things to win games. TCU comes in at 6-4 and following a pair of losses against BYU and Iowa State. This game has a lot more at stake for Houston than for the Frogs, and I love that the game is basically a pick ‘em. I will take the Cougars at home at -1.

TCU is a one-dimensional offense. They cannot run the ball, and that predictability has made their offense less and less effective as the season has worn on. Houston has a good defense, and the Frogs have struggled against good defenses all season. Houston should be able to control the game on the defensive side, especially if they can limit explosive plays. On the other side of the ball, Houston’s offense has been getting better as the season has gone along, and Conner Weigman continues to improve. That wasn’t particularly true last week when he tossed three picks at UCF, but I expect Weigman to bounce back at home and with a lot on the line. I don’t think this is a gimme for the Cougs by any means, but I like their chances to deliver at home. Trust the better team with more at stake.

TCU vs Houston Prediction: Houston -1 (-110) available at the time of publishing. Playable to -2.5.