TCU Horned Frogs

TCU Horned Frogs vs Houston Cougars Prediction, Odds and Picks for Today, 11/22/25

TDECU StadiumFOX
TCU
6-4
TCU
Today
Houston
8-2
Houston
Houston Cougars
Google News

TCU vs Houston Pickswise Expert Predictions

Point Spread PickBest Bet
Houston -1.0(-110)

The Houston Cougars host the TCU Horned Frogs on Saturday afternoon in a Big 12 battle. The Cougars are still at least theoretically alive for the Big 12 championship game at 5-2 in the conference, and they have had a fantastic season that has exceeded all expectations. In all honestly, this is a really good team that isn’t flashy, but they just keep doing the little things to win games. Meanwhile, TCU comes in at 6-4 following a pair of losses against BYU and Iowa State. This game has a lot more at stake for Houston than for the Frogs, and I love that the game is basically a pick ‘em. I will take the Cougars at home at -1.

TCU is a 1-dimensional offense. The Frogs cannot run the ball, and that predictability has made their offense less and less effective as the season has worn on. Houston has a good defense, and the Frogs have struggled against good defenses all season. Houston should be able to control the game on the defensive side, especially if they can limit explosive plays. On the other side of the ball, Houston’s offense has been getting better as the season has gone along, while Conner Weigman continues to improve. That wasn’t particularly true last week, though, when he tossed 3 picks at UCF. I expect him to bounce back at home with a lot on the line. I don’t think this is a gimme for the Cougs by any means, but I like their chances to deliver at home. Trust the better team with more at stake.

TCU vs Houston Prediction: Houston Cougars -1 (-110) available at the time of publishing. Playable to -2.5.

If you’re looking for a new sportsbook for the football postseason, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our TCU vs Houston predictions.

Photo of Chad Hartsock

Chad Hartsock

A teacher and minister by training, a fantasy sports enthusiast and sports bettor by hobby. I live in the Great Smoky Mountains, and I especially love NCAAF, NFL, NCAAB and MLB. For Chad Hartsock media enquiries, please email contact@pickswise.com.
Read more about Chad Hartsock

Featured In