Tulane Green Wave vs Ole Miss Rebels Prediction, Odds and Picks for Today, 12/20/25

Tulane and Ole Miss have met once before in the 2025 season, with the Rebels dominating in Oxford 45-10 in late September. The Green Wave managed only 104 passing yards in that game on a putrid 34.5% completion percentage. While the Rebels defense has excelled against the pass all season, I expect the Tulane offense to come out stronger this time around. Even after the poor performance in September, the Green Wave now rank 11th in passing success rate and I expect them to pull out all the bells and whistles in a do-or-die matchup.

On the other side of things, it’s no secret the Ole Miss offense is one of the top units in the country. The Rebels rank top 10 in both EPA/rush and EPA/dropback with a top-16 mark in net points per drive. Furthermore, Ole Miss has the No. 1 quality drive rate in FBS matched up against a Tulane unit ranking 94th in defensive success rate. Points will be scored by the Rebels, and with a spread set at 17-points one could expect the Green Wave to be forced into passing situations while playing from behind. With all things considered, I’ll take the over in this matchup.

Tulane vs Ole Miss prediction: Over 56.5 (-110) available at time of publishing. Playable at that number or better.

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