UCLA Bruins vs Indiana Hoosiers Prediction, Odds and Picks for Saturday, 10/25/25

The Indiana Hoosiers seem to be on a collision course to take on Ohio State to become Big Ten champions for the first time since 1967. In order to get there, the Hoosiers need to continue to stay focused and beat the conference teams in front of them. This week’s test will be at home against the UCLA Bruins. UCLA started their season 0-4, but they have gotten hot, winning their last three games. One of those wins included a 42-37 win against Penn State. UCLA’s last win came Saturday against Maryland. UCLA trailed 10-7 with five minutes remaining, but quarterback Nico Iamaleava led the Bruins to three straight scoring drives late to award UCLA with a 20-17 win. Iamaleava finished the game with 221 yards passing. It was the first time he exceeded 200 yards passing since September 12 against New Mexico. Indiana is coming off a 38-13 win against Michigan State last week. The win against Michigan State was coming off arguably the biggest win in program history for the Hoosiers when they beat Oregon 30-20. A lot of good teams may have regressed against a lesser opponent following a big win, but the Hoosiers showed they can stay focused and inspired to play each and every week. Quarterback Fernando Mendoza was nearly perfect last week, throwing 332 yards and 4 touchdowns. Mendoza completed 86% of his passes, finishing with only 4 incompletions. 

Despite the Hoosiers winning last week and overwhelming Michigan State, Indiana still was unable to cover the spread of 26.5. Indiana currently sits at a record of 4-3 against the spread this season and 2-2 against the Big Ten. They showed last week how they can win a football game by winning in every category, but still fall short in the eye of the sports bettor. It all goes to show that Indiana may be receiving too much credit and points, especially going into a matchup against a hot UCLA team. UCLA has turned their season around with three straight wins, including an identical 38-13 win over Michigan State. The difference that changed for UCLA doesn’t only include their level of play, but also the culture head coach Tim Skipper has instilled in this program. After firing DeShaun Foster, interim head coach Fisher has the Bruins players stating that they are once again having ‘fun’ when hitting the field. UCLA has established an ideology of being the underdog and that they can compete with any program. They are going to need to bring that same intensity into Memorial Stadium this weekend to keep this game competitive.

UCLA +25.5 is available at the time of publishing. Playable at that number.