UCLA Bruins vs Michigan State Spartans Prediction, Odds and Picks for Saturday, 10/11/25

The Bruins fired the shot heard around the world last week when they shocked Penn State in the Rose Bowl as a 25.5-point underdog. This is the same UCLA team that had not led at any point this season and yet they went ahead and beat the team that was ranked #2 in many polls in the pre-season, sitting inside the top ten with goal-to-go in terms of a College Football Playoff berth. Then, the Boys from Westwood struck.

You saw the images of a few die-hards storming the field while the team carried off Jerry Neuheisel. It was like watching another rendition of Remember The Titans. But that’s just it. The Bruins are coming into this game with huge let-down potential on the heels of staging the biggest upset of the season. All week long, the Bruins will be marinating in the win while Sparty waits in East Lansing preparing for this contest. The fact that the Bruins are taking back more than a converted touchdown here is telling. The oddsmakers want action on UCLA but betting them here is a week too late. Lay the points with Michigan State.

UCLA vs. Michigan State prediction: Michigan State -8.5 (-110) playable at time of publishing. Playable up to -9.