Villanova Wildcats vs Penn State Nittany Lions Prediction, Odds and Picks for Saturday, 09/13/25

The 2nd ranked team in the nation, the Penn State Nittany Lions, will welcome the Villanova Wildcats this week as they try to move to 3-0. This will be Penn State’s final tune-up game before heading into conference play against Oregon after a bye week. The Nittany Lions have defeated Nevada and Florida International University in their first 2 contests. Senior quarterback Drew Allar has looked the part early this season, throwing for 417 yards and 3 touchdowns in his first 2 games. Senior running back Kaytron Allen looks ready to go as well, rushing for 187 yards and 2 touchdowns on only 24 attempts. Villanova won their only game of the season 24-17 against Colgate. Wildcats’ quarterback, Pat McQuaide threw for 299 yards and 1 touchdown in the victory. 

This will be one of college football’s most lopsided spreads this weekend. Unfortunately, it can be difficult to tell how much pressure Penn State will put on their opponent and for how long in this game. So far this season, Penn State is 2-0, but they are 0-2 against the spread in games that have a similar outlook as this game. Penn State has been solid, but there have been inconsistencies in the first 2 games when considering their standards. Against Nevada, the passing game was great, but running the ball had its challenges. While against FIU, the rushing game went well, while passing the ball was inconsistent. With a huge, marquee matchup coming up next for Penn State against Oregon, I don’t believe that the Nittany Lions will open up the full playbook this week against Villanova. Villanova has the capability to be at least as good as Penn State’s first 2 opponents. 

Villanova vs Penn State prediction: Villanova +48.5 is available at the time of publishing. Playable at that number.

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