Virginia Cavaliers vs Duke Blue Devils Prediction, Odds and Picks for Saturday, 11/15/25

The Virginia Cavaliers are coming off their worst offensive performance of the season posting 9 points against Wake Forest while the Duke Blue Devils are in a bounce-back spot themselves after a rough loss on the road against UConn. Now, recency bias would make it difficult to rely on either side in this one. However, Virginia has continuously skated by with unlikely outcomes against a lesser schedule than what Duke has faced in 2025. A loss against UConn isn’t a great look, but the Blue Devils have a top-20 offensive unit in terms of yards per game and average over 35 points per game.

Furthermore, Duke ranks 9th in net points per drive while the Virginia defense ranks 95th in points per quality drive. Duke finishes drives, and Virginia struggles with stalling them. Offensively, Virginia has had its moments but haven’t shown much reason to believe they can keep up with the Blue Devils’ high-octane unit. Virginia’s luck seems to have run out, and I’ll back Duke to cover at home.

Virginia vs Duke prediction: Duke -4 (-110) available at time of publishing. Playable at that number or better.