Virginia Cavaliers vs North Carolina Tar Heels Prediction, Odds and Picks for Saturday, 10/25/25

We have a noon kickoff for #16 Virginia at North Carolina. North Carolina has caught a lot of attention this year as they have unexpectedly struggled under the leadership of Bill Belichick. The Heels have now dropped to 2-4 overall. On the other side, UVA is in the hunt for a conference championship game appearance, as they are undefeated in conference play, and their remaining schedule is very, very favorable. They need no slip-ups in spots like this. That said, this is the kind of spot that can be a trap game for a good team, and I think we are catching too many points here. I will go with North Carolina +10.5.

The Virginia offense has slowed over the past couple of weeks. They struggled mightily against both Washington State (301 total yards) and Louisville (237 total yards). They won both games, which is always the important part, but that might well be the case this week too. That is, I expect Virginia to be good enough to win the game (playing clean football, no bad turnovers), but maybe not to the point of running away with things. The Tar Heels are starting to look a bit more competent and together, and they still have the talent to compete. They could scare the Hoos in this one. Give me the points with the home team.

Virginia vs North Carolina Prediction: North Carolina +10.5 (-110) available at the time of publishing. Playable at that number.