Washington State Cougars vs James Madison Dukes Prediction, Odds and Picks for Today, 11/22/25

James Madison enters this matchup riding a wave of momentum and national recognition. At 9–1 overall and perfect at home, the Dukes have put themselves squarely in position to become the potential Group of Five representative in the College Football Playoff if the AAC continues cannibalizing itself. They’re 7–3 against the spread, consistent, efficient, and well-coached—everything you want from a team pushing for a major postseason berth. But that success brings pressure, and this is the part of the season where teams in JMU’s position can tighten up. With their division already clinched and a season-ending showdown with Coastal Carolina on deck, the mental landscape becomes complicated.

Washington State, meanwhile, is the classic volatility team. Its ceiling is high, and its floor is bottomless. The Cougars lost to an Oregon State team that hadn’t beaten an FBS opponent all year. They gave up 59 to North Texas, and they narrowly avoided disaster against Idaho. On the other hand, they also pushed Ole Miss to the brink in Oxford, nearly won at Virginia, and blasted San Diego State 36–13. You never know which version is showing up, but when the Cougars are engaged, they’re a genuine threat. The number offered here suggests the dangerous iteration of the Cougs show up. Upset potential is high here, grab the points.

Washington State vs James Madison prediction: Washington State Cougars +13.5 (-105) available at time of publishing. Playable to +13.

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