Washington State Cougars vs Ole Miss Rebels Prediction, Odds and Picks for Saturday, 10/11/25

The Ole Miss Rebels will try to move to 6-0 this Saturday when they welcome the 3-2 Washington State Cougars. Ole Miss is coming off a 24-19 victory two weekends ago against LSU. Quarterback Trinidad Chambliss threw for 314 yards, 1 touchdown and 1 interception. Running back Kewan Lacy led the team in rushing with 87 yards and 1 touchdown. Ole Miss’s defense is what carried the Rebels. They held Garrent Nussmeier under 20 0 yards passing, allowed only 57 yards rushing on 22 attempts, and created 1 turnover. Washington State is also coming off a victory. They defeated Colorado State 20-3 two weekends ago. Quarterback 

Zevi Eckhaus threw for 189 yards and 2 touchdowns. Running back Leo Pulalasi led the team in rushing with 50 yards. Washington State defense won the turnover battle in this game, forcing two fumbles and recovering one. This weekend we will find which one of these two teams coming off a bye will look more refreshed and sharp

All signs point in this game towards a big Ole Miss win. Ole Miss has impressed on their home field this season, winning and covering in all four games. Chambliss is impressing the nation this season under center, averaging 15.9 yards per completion. This number ranks him third among all FBS quarterbacks. Ole Miss also has an electric rushing attack fronted by Kewan Lacy. Lacy has rushed for 445 yards and 8 touchdowns so far this season. He should be set to have an explosive day against Washington State, who allow on average 150 rushing yards per game. The Rebels offense is averaging 43.3 points per game on their home field this season, and right now there is no sign that Washington State will be able to slow that down.

Ole Miss -32.5 is available at the time of publishing. Playable at that number.