Washington State Cougars vs Ole Miss Rebels Prediction, Odds and Picks for Today, 10/11/25

The Ole Miss Rebels will try to move to 6-0 this Saturday when they welcome the 3-2 Washington State Cougars. Ole Miss comes into this contest following a 24-19 victory over LSU 2 weekends ago. Quarterback Trinidad Chambliss threw for 314 yards, 1 touchdown and 1 interception. Running back Kewan Lacy led the team in rushing with 87 yards and 1 touchdown. Ole Miss’s defense is what carried the Rebels. They held Garrett Nussmeier under 200 passing yards, allowed only 57 yards rushing on 22 attempts and created 1 turnover.

Washington State comes into this game off a victory. The Cougars defeated Colorado State 20-3 just 2 weekends ago. Quarterback Zevi Eckhaus threw for 189 yards and 2 touchdowns. Running back Leo Pulalasi led the team in rushing with 50 yards. Washington State defense won the turnover battle in this game, forcing 2 fumbles and recovering 1. This weekend, we will find out which of these teams will look more refreshed and sharp coming off their respective bye weeks.

All signs point towards a big Ole Miss win. Ole Miss has impressed on their home field this season, winning and covering in all 4 games. Chambliss has impressed the nation under center, averaging 15.9 yards per completion. This number ranks him 3rd among all FBS quarterbacks. Ole Miss also has an electric rushing attack fronted by Lacy, who has rushed for 445 yards and 8 touchdowns so far this season. He should be set to have an explosive day against Washington State, who allows an average of 150 rushing yards per game. The Rebels offense is averaging 43.3 points per game on their home field this season, and there is no sign that Washington State will be able to slow that down.

Washington State vs Ole Miss prediction: Ole Miss Rebels -32.5 (-110) is available at the time of publishing. Playable at that number.

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