West Virginia Mountaineers vs Houston Cougars Prediction, Odds and Picks for Today, 11/01/25

We head to Houston for an early kickoff in what is suddenly a meaningful Big 12 game between the West Virginia Mountaineers and the Houston Cougars. While West Virginia finds themselves at the bottom of the conference standings at 0-5 and desperate for a win, the Cougars are right in the thick of the hunt for a conference crown. They are a surprising 4-1 after upending Arizona State on the road last week. With a schedule that avoids both Utah and BYU, among others, and Texas Tech already in the rearview, they have a favorable path going forward, and this team really is pretty good. That said, I think they are getting too much respect in the betting market this week, and this looks like a classic win-no-cover spot to me. I will take West Virginia +13.5.

Houston is a team with a solid defense and an adequate offense behind A&M transfer Conner Weigman. Weigman is a true dual-threat guy who is probably more dangerous with his legs than his arm. West Virginia has been respectable against dual-threat QBs, but the real key factor in this game is the Mountaineer offense. We know that Rich Rodriguez will eventually figure out a substantial offensive attack, but to this point in the season, he has more or less been holding open tryouts at quarterback. There has been way too much “panic and run” in this offense so far, but we saw some signs of life last week – as Scotty Fox Jr. got a shot. He stayed in the pocket, threw 41 times, and eclipsed 300 yards against TCU. I am not saying they have found the answer just yet, but I am suggesting that a little bit of offensive competence could definitely keep this game closer than the Cougs want it to be. Houston is usually not a team that will blow anyone out, and this could be a tricky spot to navigate.

West Virginia vs Houston Prediction: West Virginia Mountaineers +13.5 (-110) available at the time of publishing. Playable at that number.

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