Western Kentucky Hilltoppers vs LSU Tigers Prediction, Odds and Picks for Saturday, 11/22/25

This is all about LSU’s mentality and motivation, or lack thereof. The Tigers have completely unraveled this season, and the program feels like it’s stuck in neutral. They still don’t know who their next head coach will be, players are already thinking about the offseason, and the team is essentially going through the motions at this point. That is not the kind of mindset you want laying more than three touchdowns.

Western Kentucky, meanwhile, comes in at 8–2 with real momentum and something to play for. The Hilltoppers see this game as an opportunity—these chances don’t come around often for a Group of Five team. They get to walk into Tiger Stadium against a brand-name SEC opponent that clearly isn’t invested in finishing the season strong. Western Kentucky has every reason to treat this as their statement game before their finale against Jacksonville State. When you put a focused, hungry 8–2 team against a checked-out roster with no direction, this many points becomes hard to ignore. LSU may still win on raw talent, but covering this kind of number requires intensity, attention to detail, and motivation—none of which LSU has shown. Western Kentucky should compete from start to finish.

Western Kentucky vs LSU prediction: Western Kentucky +22.5 (-110) available at time of publishing. Playable to +22.