Wyoming Cowboys vs Fresno State Bulldogs Prediction, Odds and Picks for Saturday, 11/15/25

One of the final games of the night takes us to Fresno State where the Bulldogs will host the Wyoming Cowboys. Wyoming comes to town off an open week, hoping to finish the season strong. They are 4-5 at this point, and they have struggled to a 1-3 road record. Fresno also had last weekend off, but they smoked Boise State at Boise in their last game, 30-7. That does make this number a little surprising, and I expected the books to favor Fresno a bit more, especially at home. But the low point total also anticipates a slow, low-scoring contest. Still, I like the Bulldogs here and will take them to cover -3.5.

The biggest issue in this game is that both teams are working with backup QBs. For Wyoming, they lost their starter to a knee injury in the last game, and they will now turn to Landon Sims to run the offense. He was 1 for 3 for 3 yards in relief last time out, but the one completion was a touchdown. For Fresno, they benched EJ Warner a couple weeks ago and went with Carson Conklin instead. Conklin got the win against Boise, but he was 10 for 21 and only 35 yards, so do with that what you will. I think this game pretty clearly comes down to who can run the ball, and both teams will aim to do that primarily. The difference though is that Fresno State is a much tougher defense in general, and especially against the run, and I think that is the difference in the game. I will take the Bulldogs.

            Wyoming at Fresno St Prediction: Fresno St -3.5 (-110) available at the time of publishing. Playable at that number.