EPL Best Bets This Weekend: Top Picks & Predictions for September 5-6
The 2026-27 Premier League soccer season rolls on with another full slate of matches this weekend. Every team now has two games under their belt, and we're already starting to separate the contenders from the pretenders. The slate got started with Ipswich vs Liverpool on Friday, while the rest of the weekend sees all the other 18 teams in action. Our soccer experts have their EPL picks for EVERY Premier League soccer game this weekend, but for now, let's break down their hottest predictions and give our 3 EPL best bets. Let's look to bank some more profit with this weekend's EPL predictions.
EPL Best Bet: Fulham ML over Crystal Palace (+130)
Odds available at FanDuel Sportsbook and DraftKings Sportsbook at time of publishing. Playable to +120.
Fulham have lost their first two Premier League matches of the season but they can receive a boost when hosting Crystal Palace, who are also pointless.
The Cottagers showed fight in a 3-2 home loss to Chelsea in their opener and they have won at Craven Cottage this season - beating AFC Wimbledon in the EFL Cup.
Palace have lost at Everton and at home to Manchester City, conceding six goals in total, while they last won on their travels in the EPL in March.
Get the full analysis for our 5-star Fulham vs Crystal Palace best bet
EPL Best Bet: Brighton ML over Leeds (+100)
Odds available at DraftKings Sportsbook at time of publishing. Playable to -120.
Brighton will have been disappointed to have lost 4-3 at Chelsea last Sunday given the number of chances they created, but they can respond with a home win over Leeds.
The Seagulls have won five of their last six matches at the Amex Stadium, scoring at least twice in all of those victories, and that attacking flair can help beat the Whites, who have a dreadful record on the south coast.
Leeds have never won at the Amex and have lost seven of their last eight visits to Brighton.
Find out EPL stats, trends and more in our Brighton vs Leeds prediction
EPL Best Bet: Arsenal ML over Chelsea (-145)
Odds available at Fanatics Sportsbook at time of publishing. Playable to -150.
The standout game this weekend sees defending champions Arsenal host Chelsea in a London derby.
Both of these teams have made perfect starts to the new season as the Gunners downed Manchester City in the Community Shield before picking up back-to-back Premier League wins, and they are yet to concede.
Chelsea also have six points from two games, and both have been thrillers, with the Blues winning 3-2 at Fulham in the opening round and then beating Brighton 4-3 at Stamford Bridge. The Blues also have an EFL Cup win on their record over Luton.
New Chelsea boss Xabi Alonso has been tasked with turning his side back into title challengers after a disappointing season last term, and this is the acid test for the former Bayer Leverkusen and Real Madrid boss. Sunday’s derby clash also represents Arsenal’s toughest test of the new season so far.
Arsenal perhaps haven’t hit top form just yet but they haven’t really needed to get out of first gear either and they should be able to get a win over the line against Chelsea.
Mikel Arteta's team is unbeaten in 11 against their local rivals and won three of the four meetings last season. Chelsea may have been scoring heavily but they’ve also looked suspect in defense with five goals conceded in two games, so the hosts can outgun Alonso’s side and maintain their winning start.
Read our full Arsenal vs Chelsea prediction for this weekend's biggest EPL matchup
EPL Predictions for This Weekend
Want even more EPL predictions? Check out our expert picks for all 9 games this weekend below!
- Newcastle vs Bournemouth prediction
- Fulham vs Crystal Palace prediction
- Manchester City vs Coventry prediction
- Brighton vs Leeds prediction
- Brentford vs Sunderland prediction
- Nottingham Forest vs Tottenham prediction
- Hull vs Aston Villa prediction
- Everton vs Manchester United prediction
- Arsenal vs Chelsea prediction
