The Titans are currently 0-5 and have the worst offense in the NFL, averaging just 11.6 ppg. The Colts have swept Tennessee in each of the last three seasons, and another comfortable win could be on the horizon, with Tennessee unlikely to be able to slow down Jonathan Taylor.

The Titans have reached 20 points only once in five games this season, and they could be in for another low-scoring game. The Colts have been hot in the run game and will likely lean on Taylor, but Tennessee's rush defense has been solid, and a game focused on running the football could result in fewer possessions and therefore fewer points.

The Bears should get Caleb Williams back this week, and that should lead to them winning and covering against the Falcons. Atlanta lost to the Lamar Jackson-less Ravens in overtime last week, and have now covered the spread only once in their last seven at home. That trend could continue here, with the Bears boasting a hot offense.

This is a very high total for these teams, and it makes sense to go with the Under. Neither Caleb Williams nor Michael Penix Jr. is 100 percent for this matchup, and both defenses have shown enough that they can keep the offenses in check just enough to keep this total in the 40s.

The Chargers are 0-7 against the spread in their last eight games since Week 17 of 2025, while their last four opponents have a combined 13-7 record. Considering LA’s offensive struggles and Kansas City coming off the bye, look for the Chiefs to take advantage and cover at home.

The Chargers are averaging just 16.8 ppg this season, which is the third-fewest in the NFL. Given the Chiefs' defense has been solid and is coming off a bye, that situation is unlikely to change for LA. However, the Chargers D has held its own and looked good against the Broncos. They should do enough to see this total go low.

The Raiders have done a solid job stopping the run, sitting sixth in defensive EPA/Rush, and could have some success in slowing down the Bills' dominant run game behind James Cook and Josh Allen. It will be a pro-Bills crowd in Las Vegas, but this is a good opportunity for the Raiders to catch Buffalo here off a short week and a game that went to overtime.

The Bills have contested a bunch of shootouts already this season, but the Under looks the right side to be on here with this total looking a little too high. Buffalo's offense has shown it can have off-days when turning the ball over five times against the Chargers, while the Raiders' offense has stalled slightly with Kirk Cousins being intercepted in each of his last three games.