Pickswise
SF
San Francisco Giants63-89, 27-50
Today1:15 PMBusch Stadium, St. Louis
STL
St. Louis Cardinals75-77, 37-40

SF vs STL Prediction, Odds and MLB Picks for Today

SF
STL
San Francisco GiantsSt. Louis Cardinals
MLBWed, Sep 161:15 PM
Best BetMoney Line Pick

           The San Francisco Giants and St. Louis Cardinals wrap up a series on Wednesday afternoon after splitting the first two games. The Giants head back to the west coast after this game, where they will remain for the rest of the season. They somehow managed to plate 10 runs on Tuesday to get the win, but with the lineup they are trotting out these days, I have no idea how they would repeat such a feat. There is no part of me that is willing to believe in the Giants right now, and while there is not a lot of value on the Cardinals’ Money Line, this is one of those “if you see a $20 bill laying on the sidewalk, would you pick it up” situations. Give me the Cardinals to win.

           The Giants are missing at least the entire top half of their lineup to the IL right now. Willy Adames, Rafael Devers, Matt Chapman, and Casey Schmitt, among others, are all down right now. The casual baseball fan would be lying if they told you they knew even one name in the probable lineup. I just can’t get behind that. On the mound, the Giants will go with Anthony Molina. He gave up 7 runs in his last outing. It’s not like Matthew Liberatore is a stud or anything, but there is just nothing going for the Giants that I can get behind. Give me the Cardinals to win the series finale.

           Giants vs Cardinals Prediction: Cardinals ML (-160) available at the time of publishing. Playable to -170.

Exclusive Offers
See all
Polymarket — Deposit $10, Get a $50 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $50 Trading Bonus
$50
Novig — Deposit $10, Get $25 in Trade Credits
Novig
NovigDeposit $10, Get $25 in Trade Credits
$25
Underdog — First-Time Deposit Match + Keep Your $1,000,000
Underdog
UnderdogFirst-Time Deposit Match + Keep Your $1,000,000
$1,000,000
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Bet365 — Bet $10, Get $365 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $365 in Bonus Bets, Win or Lose
$365
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $350 in Bet Reset Tokens over 7 Days
FanDuel
FanDuelBet $5, Get $350 in Bet Reset Tokens over 7 Days
$350
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy