2022 NFL schedule release: Breaking down every primetime game

Los Angeles Chargers quarterback Justin Herbert (10) throws a pass against the Kansas City Chiefs in the second half at SoFi Stadium.
Photo of Andrew Ortenberg

Andrew Ortenberg


Show Bio

I'm an NFL handicapper here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up. For Andrew Ortenberg media enquiries, please email contact@pickswise.com.

The 2022 NFL schedule is out, and we’re inching closer to the start of training camps. We now know when all the marquee matchups will be during the regular season, and there’s a lot to look forward to. With schedules out oddsmakers are starting to post numbers, and I recently took a look at the opening betting lines for every Week 1 game.

Today we’ll be breaking down all the primetime games in 2022. The NFL understandably saves its best games for the standalone slots that get the most eyeballs, and there are a ton of great primetime matchups this year. Let’s dive in, and we’ll group them by day of the week:

Thursday Night Football

Week 1 – Bills (-1) at Rams (NBC)

Week 2 – Chargers at Chiefs (Amazon)

Week 3 – Steelers at Browns (Amazon)

Week 4 – Dolphins at Bengals (Amazon)

Week 5 – Colts at Broncos (Amazon)

Week 6 – Commanders at Bears (Amazon)

Week 7 – Saints at Cardinals (Amazon)

Week 8 – Ravens at Buccaneers (Amazon)

Week 9 – Eagles at Texans (Amazon)

Week 10 – Falcons at Panthers (Amazon)

Week 11 – Titans at Packers (Amazon)

Week 12 – Patriots at Vikings (Thanksgiving, NBC)

Week 13 – Bills at Patriots (Amazon)

Week 14 – Raiders at Rams (Amazon)

Week 15 – 49ers at Seahawks (Amazon)

Week 16 – Jaguars at Jets (Amazon)

Week 17 – Cowboys at Titans (Amazon)

TNF recap: There are some great Thursday Night Football games this year. TNF is often where the lesser primetime games get placed and where lower-profile teams get a chance to shine, but there are still some highlights. The season-opening showdown between the Bills and Rams is going to be a good one.

No disrespect to Commanders/Bears, Falcons/Panthers or Jaguars/Jets, but those are going to be some of the least anticipated primetime matchups of the season. Chargers/Chiefs is another highlight, but personally I’m most looking forward to Ravens/Buccaneers in Week 8. I can’t wait to see Lamar Jackson and Tom Brady go at it again.

Sunday Night Football

Week 1 – Buccaneers at Cowboys (NBC)

Week 2 – Bears at Packers (NBC)

Week 3 – 49ers at Broncos (NBC)

Week 4 – Chiefs at Buccaneers (NBC)

Week 5 – Bengals at Ravens (NBC)

Week 6- Cowboys at Eagles (NBC)

Week 7 – Steelers at Dolphins (NBC)

Week 8 – Packers at Bills (NBC)

Week 9 – Titans at Chiefs (NBC)

Week 10 – Chargers at 49ers (NBC)

Week 11 – Bengals at Steelers (NBC)

Week 12 – Patriots at Vikings (NBC)

Week 13 – Colts at Cowboys (NBC)

Week 14 – Chiefs at Broncos (NBC)

Week 15 – Patriots at Raiders (NBC)

Week 16 – Buccaneers at Cardinals (NBC)

Week 17 – Rams at Chargers (NBC)

SNF recap: What a slate of games for NBC. Al Michaels left for Amazon this offseason, so it’ll be Mike Tirico calling games opposite Cris Collinsworth for Sunday Night Football. They’ll start off with a bang with Cowboys/Bucs, which is a rematch from Week 1 last year. Steelers/Dolphins is really the only matchup on this entire SNF schedule that feels a bit underwhelming.

The first handful of weeks are absolutely stacked, and I’m also super excited for Rams/Chargers to have another battle for Los Angeles in Week 17. We’ll only see that once every four years. Speaking of things we only see every 4 years, the Bills will play the Packers, which means we get a rare Josh Allen vs Aaron Rodgers meeting.

Monday Night Football

Week 1 – Broncos at Seahawks (ESPN)

Week 2 – Titans at Bills (ESPN), Vikings at Eagles (NBC)

Week 3 – Cowboys at Giants (ESPN)

Week 4 – Rams at 49ers (ESPN)

Week 5 – Raiders at Chiefs (ESPN)

Week 6 – Broncos at Chargers (ESPN)

Week 7 – Bears at Patriots (ESPN)

Week 8 – Bengals at Browns (ESPN)

Week 9 – Ravens at Saints (ESPN)

Week 10 – Commanders at Eagles (ESPN)

Week 11 – 49ers at Cardinals (ESPN)

Week 12 – Steelers at Colts (ESPN)

Week 13 – Saints at Buccaneers (ESPN)

Week 14 – Patriots at Cardinals (ESPN)

Week 15 – Rams at Packers (ESPN)

Week 16 – Chargers at Colts (ESPN)

Week 17 – Bills at Bengals (ESPN)

MNF recap: If you’re watching primetime NFL games this season, get ready to see a lot of Russell Wilson. The league is understandably pushing his first handful of games with the Broncos hard. He’ll be on MNF in Week 1, and then again in Week 6. They’re also on Thursday Night Football in Week 5.

The first half of the MNF slate isn’t great, but it’s backloaded with a bunch of cool matchups down the stretch. Fortunately, Monday Night Football doubleheaders are back, as we’ll get a double-feature in Week 2 with Titans/Bills and then Vikings/Eagles.

Pickswise is the home of free expert NFL Picks and NFL Odds. Be sure to check out all of our season previews and NFL Futures Bets leading up to the 2022 NFL season.

Virginia Bonuses

See All
FanDuel Sportsbook
Bet $5+ on Lions vs. Packers and Receive $200 in Bonus Bets!

Sign up for a new FanDuel Sportsbook account

Bet $5 on any sporting event

Receive $200 in Bonus Bets

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at fanduel.com/sportsbook. Gambling problem? Call 1-800-GAMBLER. 21+
Bet $1 and Get $365 in Bonus Bets!

Register for a new bet365 account

Place qualifying bets of $1 or more

Get $365 in bonus bets - no matter if your bet wins or loses

Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in OH, CO, NJ, VA, IA. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer.
Bet $5 on Lions vs. Packers, Get $200 in Bonus Bets Instantly + Up to $150 in No Sweat Bets!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any sports market and get $200 in bonus bets instantly

Plus up to $150 back in bonus bets if your team loses!

Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $200 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at sportsbook.draftkings.com.
Caesars Sportsbook
$1,000 First Bet on Caesars for Lions vs. Packers!

Sign up for a new Caesars Sportsbook account and Place your 1st wager of $10 or more

Place your first wager of $50 or more and get $50 bonus bet upon settlement of your first wager

You will receive an additional $50 bonus bet each subsequent Monday

21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Min. bet $50; must be used within 14 days of receipt. See Caesars.com/promos for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER
Get $1,500 Paid Back in Bonus Bets if you Don't Win Your First Bet on Lions vs. Packers!

Register for a new BetMGM account & deposit

Place your first bet up to $1,500!

Get refunded up to $1,500 in bonus bets if you don't win

Gambling problem? Call 1-800-GAMBLER CO, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY, MA 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for Terms & Conditions. US promotional offers not available in DC, Nevada, New York or Ontario
Bet $50, Get $111 in Fred Bets + Up To $1,000 Back!

Sign up for a new account with Betfred Sports and make your first deposit

Place a $50 wager on any sport

Get $111 in Fred Bets + Up To $1,000 Back in Losses over 5 Week!

Must be 21+. T&Cs apply. Wagers only accepted in CO, AZ, IA, OH, VA, MD. Full terms available from Betfred Sports.
Get Up To $1,000 in Second Chance Bets!

Sign up for a new PointsBet account

If any of your first 10 cash bets lose (first bet per day for 10 days)

You will receive Bonus Bet(s) in the amount of the losing wager(s), up to $100 each.

Must be 21+. Full terms are available at PointsBet. Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer.
Get up to $500 Back in Bonus Bets if your First Bet Doesn't Win

Sign up for a new BetRivers account using promo code SPORTS

Make your first deposit & and bet up to $500

If your first bet loses, get up to $500 back in bonus bets

Must be 21+. Gambling Problem? Call 1-800-BETS OFF
Get a $1,000 Deposit Bonus

Create a new DraftKings Sportsbook account and make your first deposit (min $5)

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.
Underdog Fantasy
First deposit is 100% matched up to $500 with Underdog Fantasy!

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $500) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply
By signing up you agree to our terms and privacy policy