MLB Friday parlay at mega +647 odds today 6/21: Orioles keep rolling against Astros

Baltimore Orioles first baseman Ryan Mountcastle (6) celebrates with right fielder Anthony Santander (25) after hitting a home run during the fourth inning against the Kansas City Royals at Kauffman Stadium.
Photo of Caleb Wilfinger

Caleb Wilfinger


Show Bio

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
Read more about Caleb Wilfinger

The MLB season rolls on today with another exciting 15-game slate on the docket. With every team in action, there is plenty to attack and craft an MLB parlay. Let’s dive into today’s MLB parlay picks, with games getting underway at 2:20 pm ET with the Mets taking on the Cubs and concluding with the Angels taking on the Dodgers at 10:10 pm ET. You can also check out all of our MLB picks for the action on Friday, June 21.

Orioles -1.5 (+105)

White Sox vs Tigers Under 7.5 (-110)

Royals vs Rangers Under 8 (-110)

MLB parlay odds: +647

For this MLB parlay, I am going with a bet on the Orioles to win by multiple runs, plus a pair of games to go under their listed totals. Let’s break down each of the 3 legs.

We recommend betting on this MLB parlay with BetMGM, where you’ll get the best odds available and new users can get up to $1,500 in bonus bets paid back if their first wager doesn’t win! All you need to do to get started with BetMGM is click here.

Baltimore Orioles -1.5 over Houston Astros (+105)

To start off our MLB parlay, I’m going with the Baltimore Orioles on the run line. Fewer teams are hotter than the O’s at the moment, and that hot streak should continue on Friday against the Astros with budding star Grayson Rodriguez on the mound. Meanwhile, Astros starter Jake Bloss is making his MLB debut against a very difficult lineup. Rodriguez (3.20 ERA) will have a challenge on his hands against an excellent Houston lineup, but the young right-hander has been in great form over the last month, including tremendous outings against the Yankees and Phillies. On the other side, Baltimore’s lineup is hitting .273 and has an OPS of .806 in its last 10 games, while also ranking 7th against right-handed pitching this season. The O’s simply have too much firepower on the mound and at the dish, so let’s back Baltimore on the run line.

Check out our full Baltimore Orioles vs Houston Astros predictions

Chicago White Sox vs Detroit Tigers Under 7.5 (-118) 

For the second leg in our MLB parlay, I’m going with the under in this AL Central matchup between the White Sox and Tigers. These teams have been pretty miserable of late, with the Tigers having lost 4 in a row and scoring a total of 3 runs in those games, while Chicago has been the worst team in baseball all season long and shows no signs of improvement. At the very least, the starting pitching hasn’t been a major issue with either team. The White Sox will throw out Erick Fedde (3.09 ERA), who has made 4 straight road starts and has become quite reliable, allowing 2 runs or less in 5 of his last 8 outings. Detroit will counter with Jack Flaherty, who is riding a 16.2-inning scoreless streak stretching across his last 3 starts, and he has only allowed 6 hits during that span. Both pitchers should cruise against these anemic offenses, so let’s back the under in Detroit.

Read our full Chicago White Sox vs Detroit Tigers predictions

Kansas City Royals vs Texas Rangers Under 8 (-110) 

To close out this MLB parlay, I have the Royals and Rangers to go under 8 runs. Similar to the White Sox-Tigers game, these are a pair of lineups that are slumping of late. When Kansas City faces right-handed pitching on the road over the last 30 days, the Royals rank just 20th in wOBA with a wRC+ of only 89. Things aren’t much better for Texas, as the Rangers rank dead last in wOBA over the last 30 days when facing right-handed pitching, with a wRC+ of just 68. Nathan Eovaldi should produce a quality outing against a Kansas City offense that is far more threatening at home, while Brady Singer should take advantage of his favorable matchup against a Rangers lineup that is just not the same as it was a season ago. Let’s back another under and hope for a low-scoring affair in Arlington.

Read our full Kansas City Royals vs Texas Rangers predictions

By signing up you agree to our terms and privacy policy