MLB Monday parlay picks at mega +635 odds today 4/22: Yankees keep rolling

New York Yankees right fielder Aaron Judge (99) and teammates celebrate the win against the Houston Astros at Minute Maid Park.
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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
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With MLB Opening Day in the rearview mirror, we are off and running in this 2024 Major League Baseball season. Action on the diamond continues with another packed slate on Monday. The games get underway with the Yankees taking on the A’s at 1:10 pm ET and concludes with the Mets taking on the Giants at 9:45 pm ET.

And what better way to celebrate a full slate of baseball than with an MLB parlay? That’s right; I have crafted a 3-leg MLB parlay for the action at +635 odds with Bet365 Sportsbook. Below is my MLB mega parlay for Monday, and be sure to also check out all of our MLB picks for today’s action.

Yankees -1.5 (-110)  

Orioles ML (+100)   

Diamondbacks ML (-108) 

MLB parlay odds: +635

For this parlay I am going with a couple of money line wagers and a bet on the Yankees run line. Let’s break down each of the 3 legs.

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New York Yankees -1.5 over Oakland Athletics (-110)

The Yankees have been one of the best teams in baseball over the first couple of weeks of the season, and New York’s success should continue in this matchup against one of the worst teams in baseball. Yankees starter Carlos Rodon is far from perfect, but he has shown promise this season compared to his 2023 campaign — coming in with a 3.66 ERA and tallying 18 strikeouts in 19.0 innings pitched. On the other side, the A’s will turn to JP Sears — who holds a 4.94 ERA with one of the worst strikeout rates in baseball, all while allowing 10 runs on 15 hits in 20.0 innings of work. New York also has a significant edge at the plate, particularly at home. It’s the square bet, but I’ll back the better offense in this American League matchup.

Baltimore Orioles ML over Los Angeles Angels (+100) 

For the second leg of our mega parlay on Monday, I’m going with the Orioles on the money line. After a slow start at the top of the season, Baltimore has found its form as one of the better teams in baseball and it’s led to a 7-3 mark over the Orioles last 10 contests. Due to some injuries in their rotation, the O’s are going to turn to Albert Suarez on the mound for the second time this season. Suarez was rock solid in his only previous outing, tossing 5.2 innings of shutout ball with 4 strikeouts — all while limiting hard contact at a well above average level. He will be opposed by Reid Detmers, who has been terrific in his own right (1.19 ERA in 22.2 IP). However, the Orioles are the much more trustworthy offense so I’ll gladly take Baltimore at this price.

Arizona Diamondbacks ML over St. Louis Cardinals (-108) 

To close it out I’m going with the Diamondbacks on the money line against the Cardinals. For starters, we’re getting what appears to be a lopsided pitching matchup on Monday, and it looks like a good night to ride the home favorite. Don’t let Lance Lynn’s 2.18 ERA this season fool you, he’s still the same erratic pitcher as he has been over the past few seasons. With an xERA of 4.71 and an opponent exit velocity in the bottom 5 percentile of all qualified pitchers, Lynn should be in trouble against an Arizona offense that is a top 10 unit in slugging and on base percentage. On the other side, Brandon Pfaadt’s expected numbers are much better than his peripherals (3.65 xERA), plus he’s going up against a Cardinals offense that is a bottom 5 unit to this point. With the Diamondbacks swinging the bats well and holding the edge on the mound, it’s hard not to side with Arizona on the money line.

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