MLB Playoffs 2022 - World Series Odds, Picks & Best Bets: Houston is prepared for takeoff

Houston Astros starting pitcher Justin Verlander (35) wears a Space City themed uniform while delivering a pitch during the game against the Oakland Athletics at Minute Maid Park.
Photo of Keith

Keith

MLB

Show Bio

A Bostonian with a love for stats and baseball. Using knowledge and passion to find the right bet in MLB, NBA, NFL, and more. A lover of bold sports takes and sweat free plus odds picks.

Welcome to postseason baseball. After a grueling 162-game season, we are left with 12 teams to compete for the Commissioner’s Trophy. Eight teams will play in a best-of-3 wild-card series, which is followed by a best-of-5 Divisional Series with the 8 remaining teams, and the four winning teams will advance to their Conference Series that is best-of-7. After that is the World Series, and with such a balanced field this season, it could be anyone’s year.

I finished the MLB season +62.6 units for Pickswise, and I’ve chosen my two best bets for the postseason. Let’s look a look at each team’s odds to win the World Series and get right into my bets!

MLB World Series odds for 2022

Los Angeles Dodgers +340

Arguably the most dangerous offense with a starting rotation that can shut down any team. Los Angeles is ready to return to the World Series with a vengeance.

Houston Astros +425

Justin Verlander is 39 years old, but he is pitching like he is in his prime. He leads a Houston starting rotation that has been exceptional from Opening Day to now. Watch out for the Astros.

Atlanta Braves +500

They clinched the NL East and they are still hungry. Atlanta is one of the youngest teams in the postseason with rookie sensations Spencer Strider and Michael Harris adding to an already dangerous Braves team.

New York Yankees +550

Aaron Judge is the heart and soul of the Yankees offense. He may have hit 62 home runs in the regular season, but the scouting report on the Yankees is out and weaknesses are becoming seen.

New York Mets +900

The Mets led the NL East for 175 days and they did not win the division. A massive choke by the Mets forced them into the wild-card round, a series they were hoping to avoid.

Toronto Blue Jays +1300

The Blue Jays lineup is stacked. Bo Bichette was hitting the cover off the ball in September and it’s hard to forget about Vladimir Guerrero Jr., too. Toronto is ready for postseason baseball.

St. Louis Cardinals +2200

Another massive collapse was the Milwaukee Brewers losing their lead of the NL Central and then missing the playoffs all together! A late-season surge by the Cardinals has them facing the Phillies in the Wild Card round.

Philadelphia Phillies +2500

The Phillies can thank for the Brewers for their postseason spot, as they weren’t expected to be in the postseason until the last few weeks. But with a healthy lineup, the Phillies are ready to make some noise.

San Diego Padres +2800

Juan Soto, Josh Bell, Manny Machado and more. The Padres have one of the best offenses in baseball — at least on paper. They have struggled with their new stars. In an all-or-nothing season for San Diego, it’s looking like the later.

Tampa Bay Rays +2800

The Rays once again sneaked their way into the playoffs and fortunately for them, Tyler Glasnow is back. But their offense is below-average and might struggle against good pitching…like Shane Bieber, whom they are facing in Game 1 of the wild-card series.

Seattle Mariners +3000

For the first time since 2001, the Seattle Mariners are in the playoffs. It’s been a long wait for Seattle fans, but with the Blue Jays standing in their way of the Astros, it might be a short-lived postseason for the Mariners.

Cleveland Guardians +3500

Most expected to see the Chicago White Sox in this spot, but the Guardians were one of the bigger surprises of the season. With an excellent starting rotation and a top-5 bullpen, Cleveland is a dark horse this postseason.

Wild Card series: Toronto Blue Jays -1.5 games over Seattle Mariners (+180)

The wild-card round features 3 incredibly balanced matchups and 1 that should be over in 2 games. They are best-of-3 series, and each series will take place in the same location. That means this particular best-of-3 set will take place in Toronto and automatically give the Blue Jays a home-field advantage. The Mariners announced that Luis Castillo will start Game 1 and he will be opposed by the Blue Jays’ Alek Manoah, and I expect Game 2 to feature Robbie Ray in his return to Toronto against Kevin Gausman.

In Game 1 the pitching advantage goes to Manoah. He has a 2.42 ERA and a 0.92 WHIP at home while limiting opponents to a .191 batting average and a .256 OBP. His last start of the season was at home, and he threw 6 shutout innings and surrendered just 2 hits. That outing extended his streak to 15 scoreless innings over the span of his last 3 starts. As for Castillo, he’s been roughed up recently as he allowed 10 runs and 15 hits in his final 3 starts of the season, which came against Oakland twice and Kansas City – 2 pathetic offenses. As for Game 2 I expect a slightly higher-scoring game since Ray has been burned by the long ball all season, and Gausman has been prone to extra-base hits. However, neither team has announced their Game 2 starters — so that is just my best guess.

The last time the Mariners went to the playoffs was in 2001, and they lost in the ALCS to the Yankees. Fast forward to 2022 and I don’t expect Seattle to make it as far. Toronto ended the regular season on a tear at the plate, ranking 1st in BA, 2nd in OBP and 2nd in OPS in the final 30 days. Bo Bichette is seeing a softball for a baseball, as he finished September with a .403 average, and you can’t pitch around him because he is followed by Vladimir Guerrero Jr, Teoscar Hernández, Alejandro Kirk and more. And don’t forget about George Springer leading off; he hit .333 in his final 15 games. Toronto boasts one of the best offenses in the postseason from the leadoff spot to the 9-hole, and Seattle won’t be able to contain all 9 hitters.

The price of the Blue Jays to win the series is steep at -174 on FanDuel and -170 at DraftKings, so instead, I’ll back Toronto to sweep the Wild Card series at home at excellent value.

American League winner: Houston Astros (+175)

The Astros have the most balanced team in the American League. The reason my best bet isn’t for the Astros to win the World Series is because of the star-studded Dodgers in the National League. But the Astros should win the AL without much trouble, in my opinion, as they earned a bye through the wild card — which means they get to rest until next Tuesday while their competition has to play at least 2 games and maybe 3. That gives their starting rotation and bullpen extra rest that they haven’t had all season long — an immediate advantage.

Houston has been exceptional the entire season, but to factor in their trade-deadline acquisitions, I’ll focus on their second half of the season. Their starting rotation finished 1st in ERA and 2nd in FIP, while their bullpen finished 4th in ERA and 2nd in FIP. Their rotation is led by future 2022 AL Cy Young winner Justin Verlander and followed by Framber Valdez, Lance McCullers Jr. and Cristian Javier. The highest ERA of those four starters was by Valdez, who finished with a 2.82 ERA. On any other team, he would be their ace, and that just proves how deep the Houston rotation is. Their offense finished the second half of the season ranked 7th in BA, 9th in OBP and 7th in OPS, and it’s hard to narrow down one hitter than another considering Jose Altuve hit .300, and Yordan Alvarez had a 1.019 OPS. The entire lineup contains the ability to hit for power and contact, a mix that is incredibly rare in baseball.

There is not one team in the American League that has a good chance to beat the Astros in a 7-game series. Alek Manoah and Kevin Gausman will be on too short of rest to pitch in game one of the series if Toronto wins the wild-card round, and as we saw in the second half of the season if the Blue Jays have to rely on Mitch White or Jose Berrios, they lose. I anticipate a 3-1 series in favor of Houston in the ALDS if it’s against the Blue Jays, which will bring the Astros to the ALCS to face either the Tampa Bay Rays, Cleveland Guardians, or New York Yankees. That section of the postseason bracket is by far the weakest, and I expect the Yankees to come out victorious in their divisional series, but if the Guardians or Rays could complete an upset, then it would make it even easier for Houston. But if it is New York, we have seen numerous weaknesses come to light in the second half of the season. The Yankees’ bullpen is no longer elite, their rotation is prone to the long ball, and their offense will live and die by Aaron Judge.

It could be Houston’s year to win it all, but admittedly the Dodgers scare me, so backing Houston to win the American League is one of my favorite bets to make in the postseason.

Pickswise is the home of free MLB Picks. Check out the latest MLB Prop Bets and MLB Parlays as well as our MLB Best Bets from the experts.

Virginia Bonuses

See All
Unibet

$100

Get a $100 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $100 risk-free!

Get refunded up if you lose up to $100

New players only. Terms & conditions apply. 21+. VA only.

FanDuel Sportsbook

$1,000

Get a $1,000 No Sweat First Bet

Sign up for a new FanDuel Sportsbook account and make your first deposit of $10+

Place your first bet up to $1,000!

Get refunded if you lose up to $1,000

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at fanduel.com/sportsbook.

BetRivers

$500

Get a $500 Risk-Free Bet

Sign up for a new BetRivers account using promo code PICKSWISE

Make your first deposit & get up to $500 in free bets

To get $500 in free bets, wager $500

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF

BetMGM

$200

Bet $10, Win $200 if Any NBA Team Hits a Three Pointer!

Sign up for a new betting account with BetMGM

Place a pre-game moneyline wager of at least $10 on a NBA game

Win $200 in free bets if any team hits a three pointer

21+. Terms & conditions apply.

DraftKings

$150

Bet $5 & Win $150 If Your First Moneyline Bet Wins!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on the pre-game Moneyline in any sport

Win $200 if your team wins

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.

PointsBet

$800

Get 4x $200 In Free Bets

Sign up for a new PointsBet account

Bet up to $200 and If you lose, you get a refund

You will receive Free Bet(s) in the amount of the losing wager(s), up to $200 each for four days.

Must be 21+. Full terms are available at PointsBet.

Caesars Sportsbook

$1,250

Get a $1,250 risk-free bet

Sign up for a new Caesars Sportsbook account

Place your first bet of $10 or more

If your first bet loses, you’ll receive a refund up to $1,250 from Caesars in free bets

21+. Terms and conditions apply.

BetMGM

$200

Bet $10, Get $200 if Any NHL Team Scores A Goal

Sign up for a new betting account with BetMGM

Place a pre-game moneyline wager of at least $10 on a NHL game

Win $200 in free bets if any teams scores a goal

21+. Terms & conditions apply.

BetMGM

$1,000

Get a $1,000 Risk Free Bet

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

PointsBet

$500

Get 5x $100 in Free Bets

Sign up for a new PointsBet account

Make a bet of up to $100 and receive a refund if you lose

Get this offer once a day for the first 5 days you sign up

Must be 21+. Full terms are available at PointsBet.

DraftKings

$1,000

Get a $1,000 Deposit Bonus

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.

PointsBet

$2,000

Get $2,000 in Free Bets

Register for a new PointsBet account & deposit

Receive a free bet refund up to $500 if your first fixed odds bet loses

& a free bet refund up to $1,500 if your first two PointsBetting Wager loses

Must be 21+. Full terms are available at PointsBet.

Monkey Knife Fight

$100

Claim Instant Deposit Match up to $100 + Free $5 game

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

TVG

$200

Get Your First Single-Horse Win Wager Back Up to $200 if you don't win

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $200

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

TwinSpires

$200

Get a $200 Sign-Up Bonus with Twinspires Racebook!

Open your TwinSpires.com account using offer code BET200

$200 bonus cash will be credited in increments of $100 for every $400 wagered

To earn the full $200 bonus players must wager $800 within 30 days

21+. Terms and conditions apply.

Underdog Fantasy

$100

First deposit is 100% matched up to $100 with Underdog Fantasy

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $100) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply