MLB Best Bets

Welcome to the home of our MLB best bets. Our expert handicappers analyze all of the latest team news, statistics, form, and trends to bring to you our MLB best bets. For the remainder of our MLB picks, including a pick for each game of the MLB season, head over to our MLB Picks and MLB Predictions pages.

Our MLB best bets will be released at the latest at 11 am EST once all lines have become available with sportsbooks.

Filter Picks

Bet Type

Money Line (1)Game Totals (1)

Experts

Pickswise Experts (2)

9:40 PM ET

Yesterday

Dodgers

Padres

Money Line PickBest Bet

LA Dodgers Win(-160)

Reasoning

My favorite rivalry in baseball right now is the Los Angeles Dodgers vs the San Diego Padres. With the win last night, the Padres pulled half a game ahead of the Dodgers in the NL West, which only adds to this rivalry. These games are must-watch, with lots of energy and spice. On Monday, the Dodgers gave Yamamoto the standard treatment, where he pitches lights out, allows barely anything, but the offense refuses to score. Happens all the time. Michael King was exceptional on the other side though, and it pushed the Padres’ winning streak to 4 straight (and ended a 5-game winning streak for the Dodgers). Look for the Dodgers to rebound on Tuesday, and this is a spot where you can either hammer the Money Line or roll the dice on the Run Line. I’ll take LA to win.

Emmet Sheehan and Giffin Canning will toe the rubber. This should be a lopsided mismatch. Sheehan had a rough start to the season, but he has allowed 2 runs or less in 4 of his last 5 starts. He is far better than Canning, who I am surprised to find pitching for the Padres. He has made 3 starts this month, allowing 6 runs in each of the last 2 outings. It is not likely that he will find better results against the mighty Dodgers. I am not sure how you would make a case for the Padres tonight with Canning on the mound, whom most of the Dodgers have also seen several times. Give me Sheehan and the Dodgers to win this one and even the series.

Dodgers vs Padres Prediction: Dodgers ML (-160) available at the time of publishing. Playable to -180.

Sign up for Polymarket RIGHT NOW to get instant access and a $50 trading bonus after you make your first $20 deposit! You can join Polymarket by clicking here and trade on our Dodgers vs Padres predictions.

BET -165 NOW WITH

Chad Hartsock

9:40 PM ET

Yesterday

Giants

Diamondbacks

Game Totals PickBest Bet

Over 8.5(-120)

Reasoning

The San Francisco Giants look for revenge in the second game of this series in the Valley of the Sun after falling 12-2 on Monday night. The 12 runs allowed were the most yielded on the road this season, and the second-most at any venue. The Over has cashed in three straight games for the Giants, averaging 6.0 runs per game (RPG) on offense in that 3-game span, while allowing 5.7 RPG. The Giants have allowed 4 or more runs in 5 of the past 6 outings. San Francisco turns to RHP Landen Roupp (5-4, 3.49 ERA, 1.14 WHIP) to get it back into the win column. However, he has really struggled in three May outings, going 0-3 with a 5.93 ERA, including 8 runs allowed in 9.2 IP across a pair of road starts.

The Diamondbacks have piled up 20 runs in the past 2 games, and 8 or more runs in 3 of the past 4 outings. Of course, 3 of those games were on the road at Coors Field, so that always helps bump up the numbers. The Over is 4-2 in the past 6 games, however, as the offense is back. The Snakes turn to RHP Ryne Nelson (1-3, 5.40 ERA, 1.16 WHIP), and he has been very giving this season. At home, he is 0-2 with a 9.18 ERA across 4 outings, allowing 17 runs in just 16.2 IP with 5 homers served up, and teams are hitting .282 against him as well. With Roupp struggling in May, and Nelson terrible for most of the season, let’s go with the over on Tuesday.

Giants vs Diamondbacks prediction: Over 8.5 (-120) at time of publishing. Playable to 9.5.

Sign up for Polymarket RIGHT NOW to get instant access and a $50 trading bonus after you make your first $20 deposit! You can join Polymarket by clicking here and trade on our Giants vs Diamondbacks predictions.

BET o8.5 NOW WITH

Joe Williams

MLB Best Bets

58.3%

Win %

21Wins

15Losses

0Pushes

Percentage only includes Wins and Losses

What Are Our MLB Best Bets

At Pickswise our expert handicappers spend hours analyzing each match of the MLB season, delving into the latest MLB statistics, team news, travel, schedule, weather, trends to name just a few angles we cover and consider.

With a typical MLB regular season containing a total of 2,430 games, researching this many games in the required depth is an exhaustive task. Our experts take care of all of that, so you don’t have to.

With a large number of games each day throughout the 2026 season and up to 15 matches on any given day (or sometimes more if there are doubleheaders), being selective in your wagers is key in trying to secure a long-term profit. That’s where our confidence ratings and MLB best bets come into play.

Our MLB Best bets are exactly what you would expect them to be, our top picks for today’s slate of games, with our reasoning and analysis for each MLB Best Bet alongside.

How Do I Know What Your MLB Best Bets Are For Today?

Our MLB best bets for today will appear right here, on our MLB best bets page.

Across our site, our expert handicappers provide the best free MLB predictions and match previews for every game of the MLB season and include a confidence rating for each of our MLB predictions.

The rating system runs from one to three stars, the more stars, the more confidence in the pick, with the most confident MLB Picks highlighted here on our MLB best bets page.

As soon as the sportsbooks release the odds and lines for today’s MLB games our expert handicappers will be combining these with their research to find today’s MLB best bets.

Where Should I Wager On Your MLB Best Bets Today?

MLB is one of the most popular sports that sports bettors place wagers on and as such, most online sportsbooks will offer competitive prices about a plethora of markets on each game.

While we preview every game of the MLB season from Opening Day through to the World Series, betting on every game is not recommended, with a betting strategy very much needed to see you turn a profit over the season.

A big part of this strategy is making sure you are wagering on our MLB Predictions at the best possible odds. With each sportsbook pricing up markets differently, be sure to shop around to make sure you are on our MLB Best Bets at the best odds available.

All of our MLB picks are accompanied by the best available odds and which online sportsbooks are offering them, as well as our detailed reasoning for the pick.

If you don’t yet have an account with one of the sportsbooks listed as having the best odds, why not check out our Sportsbook Bonuses Page to see the latest promo codes available in your state and get off to a flyer with a great sign up bonus. To see our thoughts on the leading online sportsbooks, check out our Online Sportsbook Reviews Page right here.

Baseball Betting – Best Baseball Bets Today

Baseball betting can be tricky with so many games played each day and across the season – 2,340 in just the regular season alone! There are also many different ways that you can wager on baseball betting, from traditional markets like the Money Line, Run Line, and Runs Totals, to MLB Prop Bets such as player runs, hits, and strikeouts, or Team Props such as team runs or innings betting. Our baseball best bets page is the best place to start when looking at your baseball betting today. Here our expert handicappers post their best baseball bets on today’s slate with full analysis, reasoning, and odds. Check out our MLB Predictions and MLB Picks pages for all of our other baseball betting previews and picks.

MLB Lock Of The Day – MLB Lock Picks Today

Looking for MLB Lock Picks today? Well, you’re in the right place. At Pickswise, our MLB Lock picks will be right here on our MLB Best Bets page every day of the regular season and into the MLB playoffs. With 2,430 regular-season games played alone in an MLB season, and numerous games played on any given day, it’s not wise to bet on them all. What you’ll find here is our MLB expert handicappers’ MLB Lock Of The Day, our most confident pick. Each MLB Lock Pick will be accompanied by a full match preview and analysis including why we have this as being a lock. You can also check out how our MLB Lock picks have fared across the season, with our 2026 MLB Best Bets Record displayed at the top of this page.

Be sure to check out our MLB Picks and MLB Predictions for all of our other MLB bets on today’s games.