NFL Week 1 Betting Guide: Picks, Predictions & Props for the NFL This Week

Welcome to the Pickswise NFL Week 1 betting guide! We have arrived at the beginning of the regular season, which kicked off on Thursday night with a big win for the defending Super Bowl champion Philadelphia Eagles over the visiting Dallas Cowboys. 

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the opening slate of the NFL regular season.

NFL Week 1 picks 

• NFL picks against the spread and total for EVERY Week 1 game 
• NFL best bets  
• NFL parlays 

NFL Week 1 expert betting picks and predictions 

• Pickswise experts’ best bets 
• NFL Week 1 mega parlay (+2512 odds!) 
• Baltimore Ravens vs Buffalo Bills SNF Same Game Parlay 

NFL Week 1 prop bets 

• Week 1 touchdown scorer best bets 
• Sunday player prop best bets  
• Sunday Night Football prop bets 
• Sunday Night Football touchdown scorer bets

NFL Week 1 big-game predictions 

• Dolphins vs Colts predictions
• Steelers vs Jets predictions
• Raiders vs Patriots predictions
• Commanders vs Giants predictions
• Lions vs Packers predictions
• 49ers vs Seahawks predictions
• Texans vs Rams predictions
• Ravens vs Bills predictions