NFL Week 13 Betting Guide: Picks, Predictions & Best Bets for the NFL This Week

Welcome to the Pickswise NFL Week 13 betting guide! The 2025 NFL season is nearing the home stretch and it continued on Thanksgiving Day with a trio of excellent football games. Now we can focus on a 12-game Sunday slate. Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the Week 13 slate of the NFL regular season. 

NFL Week 13 picks  

• NFL picks for EVERY Week 13 game 
• NFL best bets
• NFL parlays  

NFL Week 13 expert betting picks and predictions  

• NFL Week 13 parlay  — can we cash another parlay at +2210 odds?
• NFL Broncos vs Commanders Same Game Parlay

NFL Week 13 prop bets  

• Week 13 touchdown scorer best bets
• NFL Week 13 player props
• Sunday Night Football player props

NFL Week 13 predictions  

• 49ers vs Browns predictions
• Texans vs Colts predictions 
• Falcons vs Jets predictions 
• Cardinals vs Buccaneers predictions 
• Bills vs Steelers predictions 
• Vikings vs Seahawks predictions
• Broncos vs Commanders predictions