NFL Week 2 Betting Guide: Picks, Predictions & Props for the NFL This Week 

Welcome to the Pickswise NFL Week 2 betting guide! The 2025 campaign is off and running and it continued with Green Bay becoming the first team to reach 2-0 when it defeated Washington on Thursday Night Football. Now we can focus on a 13-game Sunday slate. 

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the opening slate of the NFL regular season. 

NFL Week 2 picks  

• NFL picks against the spread and total for EVERY Week 2 game  
• NFL best bets   
• NFL parlays  

NFL Week 2 expert betting picks and predictions  

• Pickswise experts’ best bets   
• NFL Week 2 mega parlay (+2755 odds!)   
• Daily Fantasy advice 

NFL Week 2 prop bets  

• Week 2 touchdown scorer best bets 
• Sunday player prop best bets
• Sunday Night Football touchdown scorer bets 

NFL Week 2 big-game predictions  

• Jaguars vs Bengals predictions 
• Giants vs Cowboys predictions 
• Seahawks vs Steelers predictions 
• Broncos vs Colts predictions 
• Eagles vs Chiefs predictions 
• Falcons vs Vikings predictions 
• Buccaneers vs Texans predictions 
• Chargers vs Raiders predictions