NFL Week 4 Betting Guide: Picks, Predictions & Props for the NFL This Week

Welcome to the Pickswise NFL Week 34betting guide! The 2025 campaign is well underway and it continued with the Seattle Seahawks knocking off the Arizona Cardinals on a game-winning field goal on Thursday Night Football. Now we can focus on a 13-game Sunday slate. Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the opening slate of the NFL regular season. 

NFL Week 4 picks  

• NFL picks for EVERY Week 4 game 
• NFL best bets
• NFL parlays  

NFL Week 4 expert betting picks and predictions  

• Pickswise experts’ best bets — find out our top plays across Sunday’s card
• NFL Week 4 mega parlay — we cashed a +2512 parlay in Week 1!
• NFL Packers vs Cowboys Same Game Parlay

NFL Week 4 prop bets  

• Week 4 touchdown scorer best bets
• Sunday player prop best bets
• Sunday Night Football player props
• Sunday Night Football touchdown scorer best bets

NFL Week 4 predictions  

• Eagles vs Bucs predictions 
• Colts vs Rams predictions 
• Giants vs Chargers predictions 
• Panthers vs Patriots predictions 
• Jaguars vs 49ers predictions 
• Ravens vs Chiefs predictions 
• Packers vs Cowboys predictions